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PAX8 Monoclonal antibody, PBS Only (Capture)

PAX8 Monoclonal Antibody for Cytometric bead array, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

human

Applications

Cytometric bead array, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1C5A11

Cat no : 60144-1-PBS

Print datasheet

Synonyms

PAX-8, PAX 8, Paired box protein Pax-8, Paired box protein Pax 8, paired box 8

验证数据展示

  • Cytometric bead array standard curve of MP50408-4

    Cytometric bead array standard curve of MP50408-4

    Cytometric bead array standard curve of MP50408-4, PAX8 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 60144-1-PBS. Detection antibody: 68979-2-PBS. Standard:Ag0306. Range: 0.781-100 ng/mL.

  • Cytometric bead array standard curve of MP50408-5

    Cytometric bead array standard curve of MP50408-5

    Cytometric bead array standard curve of MP50408-5, PAX8 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 60144-1-PBS. Detection antibody: 68979-1-PBS. Standard:Ag0306. Range: 1.563-100 ng/mL.

Planning an IHC experiment? We recommend our IHCeasy PAX8 Ready-To-Use IHC Kit. PAX8 primary antibody included.

产品信息

60144-1-PBS targets PAX8 as part of a matched antibody pair:

MP50408-4: 60144-1-PBS capture and 68979-2-PBS detection (validated in Cytometric bead array)

MP50408-5: 60144-1-PBS capture and 68979-1-PBS detection (validated in Cytometric bead array)

Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

Tested Applications Cytometric bead array, Indirect ELISA Application Description
Tested Reactivity human
Immunogen PAX8 fusion protein Ag0306 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name paired box 8
Synonyms PAX-8, PAX 8, Paired box protein Pax-8, Paired box protein Pax 8, paired box 8
Calculated Molecular Weight 48 kDa
GenBank Accession NumberBC001060
Gene Symbol PAX8
Gene ID (NCBI) 7849
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ06710
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas.

PAX8 has 5 isoforms with calculated MW 31kd, 34kd, 41kd, 43kd and 48kd. And there is a 60kd band corresponding to the electrophoretic mobility of PAX8 (PMID:15650356).