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PCNA-I1

PCNA-I1 是PCNA(增殖细胞核抗原)抑制剂。它能够直接与 PCNA 三聚体结合(Kd:0.41 μM)，在体内外均表现出抗肿瘤活性。

CAS号

444930-42-1

分子式

C17H14N2O2S

主要靶点

Others

仅限科研使用

Cat No : CM10556

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Synonyms

验证数据展示

  • CAS No.: 444930-42-1

    PCNA-I1
    CAS#: 444930-42-1

产品信息

PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer.

CAS号 444930-42-1
分子式 C17H14N2O2S
主要靶点 Others
主要通路 其他
分子量 310.37
纯度 97.64%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

Intravenous administrations of PCNA-I1 significantly retarded growth of LNCaP tumors of in nude mice without causing detectable effects on mouse body weight and hematology profiles[1].

体外活性

PCNA-I1 induced DNA damage and apoptosis in both LNCaP and PC-3 cells and enhanced DNA damage and apoptosis triggered by cisplatin.?PCNA-I1 also induced autophagy in PC-3 cells.?A short-term pretreatment with PCNA-I1 reduced colony formation by 50% in both cell lines.[1]

溶解度

DMSO:3.1 mg/mL (10 mM),Sonification is recommended.

参考文献

1.Dillehay K L , Lu S , Dong Z . Antitumor Effects of a Novel Small Molecule Targeting PCNA Chromatin Association in Prostate Cancer[J]. Molecular Cancer Therapeutics, 2014, 13(12):2817-26. 2.Dillehay K L , Seibel W L , Zhao D , et al. Target validation and structure–activity analysis of a series of novel PCNA inhibitors[J]. Pharmacology Research & Perspectives, 2015, 3(2).

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
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C1   V1   C2   V2