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- KD/KO Validated
PCSK5 Polyclonal antibody
PCSK5 Polyclonal Antibody for IHC, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse and More (1)
Applications
IHC, ELISA and More (1)
Conjugate
Unconjugated
验证数据展示
经过测试的应用
| Positive IHC detected in | human kidney tissue, human brain tissue, human skin tissue, human heart tissue, human testis tissue, human spleen tissue, mouse brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
| Application | Dilution |
|---|---|
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
发表文章中的应用
| KD/KO | See 1 publications below |
| IHC | See 1 publications below |
| IF | See 1 publications below |
产品信息
16470-1-AP targets PCSK5 in IHC, IF, ELISA applications and shows reactivity with human, mouse samples.
| Tested Applications | IHC, ELISA Application Description |
| Cited Applications | IHC, IF |
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, rat |
| Immunogen | PCSK5 fusion protein Ag9552 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | proprotein convertase subtilisin/kexin type 5 |
| Synonyms | hPC6, PC5, PC6, PC6A, PCSK5, Proprotein convertase 5, Proprotein convertase 6, SPC6 |
| Calculated Molecular Weight | 102 kDa, 207 kDa |
| Observed Molecular Weight | 210 kDa |
| GenBank Accession Number | BC012064 |
| Gene Symbol | PCSK5 |
| Gene ID (NCBI) | 5125 |
| RRID | AB_2283381 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q92824 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
PC5 ,a mammalian kex2-like processing endoprotease, mediates posttranslational endoproteolytic processing for several integrin alpha subunits.It has been identified in rat and mouse endocrine and neuroendocrine tissues,and is encoded by multiple mRNAs that generate two splice variant isoforms referred to as PC5A (102KDa) and PC5B (207KDa) .PC5A is smaller than PC5B and it can be processed into two forms (117 kDa and 65 kDa) in neuronal cells(PMID:11457520).
实验方案
| Product Specific Protocols | |
|---|---|
| IHC protocol for PCSK5 antibody 16470-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Mol Med Rep MicroRNA‑338‑3p regulates age‑associated osteoporosis via targeting PCSK5.
| ||
Biochem Biophys Rep Secreted factors from adipose tissue-derived mesenchymal stem cells suppress oxygen/glucose deprivation-induced cardiomyocyte cell death via furin/PCSK-like enzyme activity. | ||
Mol Cell Biochem PCSK5 downregulation promotes the inhibitory effect of andrographolide on glioblastoma through regulating STAT3 | ||
Circ Heart Fail Overexpression of ATP5F1A in Cardiomyocytes Promotes Cardiac Reverse Remodeling |
