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BMS-1

BMS-1 (PD-1/PD-L1 inhibitor 1)是一种 PD-1/PD-L1蛋白质/蛋白质相互作用的抑制剂，IC50为 6 到 100 nM。

CAS号

1675201-83-8

分子式

C29H33NO5

主要靶点

PD-1/PD-L1|Apoptosis

仅限科研使用

Cat No : CM05769

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Synonyms

PD-1/PD-L1 inhibitor 1|PD1-PDL1 inhibitor 1

验证数据展示

  • CAS No.: 1675201-83-8

    BMS-1
    CAS#: 1675201-83-8

产品信息

PD1-PD-L1 inhibitor 1 (PD1-PD-L1-IN-1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows Ys to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.

CAS号 1675201-83-8
分子式 C29H33NO5
主要靶点 PD-1/PD-L1|Apoptosis
主要通路 凋亡|细胞周期|免疫与炎症
分子量 475.58
纯度 99.81%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 PD-1/PD-L1 inhibitor 1|PD1-PDL1 inhibitor 1

靶点活性

PD-1/PD-L1 interaction:0.006 μM

溶解度

DMSO:29 mg/mL (60.98 mM)

参考文献

1.Chupak Louis S,et al. From PCT Int. Appl. (2015), WO 2015034820 A1 20150312.
2.Choi J G, Kim Y S, Kim J H, et al. Anticancer effect of Salvia plebeia and its active compound by improving T-cell activity via blockade of PD-1/PD-L1 interaction in humanized PD-1 mouse model[J]. Frontiers in immunology,. 2020, 11.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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