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PDCD5 Polyclonal antibody

PDCD5 Polyclonal Antibody for WB, IHC, ELISA
Cat No. 12456-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, ELISA and More (2)

PDCD5, programmed cell death 5, Protein TFAR19, TFAR19

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inhuman heart tissue, PC-3 cells, human brain tissue, A549 cells
Positive IHC detected inhuman endometrial cancer tissue, human skin cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:1000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

12456-1-AP targets PDCD5 in WB, IHC, IP, ELISA, IF applications and shows reactivity with human samples.

经测试应用 WB, IHC, ELISA Application Description
文献引用应用WB, IHC, IP, IF
经测试反应性 human
文献引用反应性human
免疫原 PDCD5 fusion protein Ag3122 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 programmed cell death 5
别名 PDCD5, programmed cell death 5, Protein TFAR19, TFAR19
计算分子量 125 aa, 14 kDa
观测分子量 14 kDa
GenBank蛋白编号BC015519
基因名称 PDCD5
Gene ID (NCBI) 9141
RRIDAB_2162450
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDO14737
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

PDCD5, also called TFAR19 (TF1 cell apoptosis-related gene 19), was first identified as a gene up-regulated in TF-1 cells under-going apoptosis (PMID: 9920759). PDCD5 can promote pro-grammed cell death in different cell types in response to various stimuli and also enhance TAJ/TROY-induced paraptosis-like cell death (PMID: 15020679). During apoptosis, PDCD5 is rapidly upregulated and translocates from the cytoplasm to nucleus (PMID: 11741587). PDCD5 is a positive regulator of Tip60 and also has a potential ability to interact with p53 (PMID: 22914926, PMID: 19308289). Recent studies have also revealed that PDCD5 may be a suppressor gene and expressed at lower levels in many cancers, including hepatocellular carcinoma, breast cancer, gastric cancer, cervical cancer, lung cancer, astrocytic gliomas, and in leukemia.

实验方案

Product Specific Protocols
WB protocol for PDCD5 antibody 12456-1-APDownload protocol
IHC protocol for PDCD5 antibody 12456-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
IHC, WB

Nat Commun

Club cell-specific role of programmed cell death 5 in pulmonary fibrosis.

Authors - Soo-Yeon Park
WB

Nat Commun

Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response.

Authors - Hyo-Kyoung Choi
  • KD Validated
humanWB

J Nanobiotechnology

Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia.

Authors - Lin Lin
humanWB

J Cell Physiol

Thyroid stimulating hormone aggravates diabetic retinopathy through the mitochondrial apoptotic pathway.

Authors - Dong Lin
humanWB

Sci Rep

Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5.

Authors - Soo-Yeon Park
humanWB, IF

Cancer Lett

DNAJB1 destabilizes PDCD5 to suppress p53-mediated apoptosis.

Authors - Xiandan Cui
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