验证数据展示
产品信息
55355-1-AP targets PEAK1 in ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | NKF3 kinase family member |
| 别名 | KIAA2002, NKF3 kinase family member, PEAK1, SGK269, Sugen kinase 269, Tyrosine protein kinase SgK269 |
| 计算分子量 | 193 kDa |
| GenBank蛋白编号 | NM_024776 |
| 基因名称 | PEAK1 |
| Gene ID (NCBI) | 79834 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9H792 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Aliquoting is unnecessary for -20oC storage. |
背景介绍
PEAK1, also named as SGK269 and KIAA2002, belongs to the protein kinase superfamily. (PEAK1). It is a 190-kDa nonreceptor tyrosine kinase that localizes to actin filaments and focal adhesions. PEAK1 undergoes Src-induced tyrosine phosphorylation, regulates the p130Cas-Crk-paxillin and Erk signaling pathways, and operates downstream of integrin and epidermal growth factor receptors (EGFR) to control cell spreading, migration, and proliferation. Perturbation of PEAK1 levels in cancer cells alters anchorage-independent growth and tumor progression in mice. Notably, primary and metastatic samples from colon cancer patients display amplified PEAK1 levels in 81% of the cases. PEAK1 is an important cytoskeletal regulatory kinase and possible target for anticancer therapy. This antibody is specific to PEAK1.