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PF-06446846

PF-06446846 是口服有活性的 PCSK9抑制剂。它能够在密码子区域附近阻断 80S ribosome，选择性地直接抑制 PCSK9 的翻译。

CAS号

1632250-49-7

分子式

C22H20ClN7O

主要靶点

Others

仅限科研使用

Cat No : CM05763

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Synonyms

验证数据展示

  • CAS No.: 1632250-49-7

    PF-06446846
    CAS#: 1632250-49-7

产品信息

PF 06446846 is a potent and selective PCSK9 inhibitor

CAS号 1632250-49-7
分子式 C22H20ClN7O
主要靶点 Others
主要通路 其他
分子量 433.9
纯度 99.40%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?PF-06446846 is highly selective for the inhibition of PCSK9 translation.?The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts.

溶解度

DMSO:4.34 mg/mL (10 mM),Sonification is recommended.

参考文献

1.Lintner N G , Mcclure K F , Donna P , et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain[J]. PLoS Biology, 2017, 15(3):e2001882-.

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