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PFK-015

PFK-015 (PFK15) 是一种有效的 PFKFB3 抑制剂，对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性，IC50为20 nM。

CAS号

4382-63-2

分子式

C17H12N2O

主要靶点

Glucokinase|Autophagy

仅限科研使用

Cat No : CM05839

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Synonyms

PFK 015|PFK15

验证数据展示

  • CAS No.: 4382-63-2

    PFK-015
    CAS#: 4382-63-2

产品信息

PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).

CAS号 4382-63-2
分子式 C17H12N2O
主要靶点 Glucokinase|Autophagy
主要通路 代谢|自噬
分子量 260.29
纯度 98.94%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 PFK 015|PFK15

靶点活性

PFKFB3:110 nM|PFKFB3:20 nM

体内活性

在Jurkat T-细胞白血病细胞和H522肺腺癌细胞中,PFK-015可使F26BP、葡萄糖摄取及细胞内腺嘌呤核苷三磷酸水平降低。PFK-015还对一系列癌细胞的生长具有明显的抑制作用。

体外活性

PFK-015（25 mg/kg,i.p.）对同源小鼠体内LLC肿瘤的生长、转移扩散及葡萄糖代谢具有抑制作用.在三个人异种移植的无胸腺癌症小鼠模型中,PFK-015与公认化疗药物的抗癌效果相似.PFK-015有适当的体内药代动力学性质.

溶解度

DMSO:26 mg/mL (100 mM)

细胞实验

Viability is determined using trypan blue exclusion. Cells were incubated in 20% trypan blue for 5 minutes. Cells excluding trypan blue are counted using a standard hemocytometer to determine the total number of viable cells. Experiments are conducted in triplicate. (Only for Reference)

参考文献

1.Clem BF, et al. Mol Cancer Ther. 2013, 12(8), 1461-1470.
2.Zhang Y, Wang X, Li X, et al. Synergistic effect of colistin combined with PFK-158 against colistin-resistant Enterobacteriaceae[J]. Antimicrobial agents and chemotherapy. 2019, 63(7): e00271-19.

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