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PH-002

PH-002 是一种抑制载脂蛋白 E4 神经内分子相互作用的抑制剂(IC50:116 nM)。

CAS号

1311174-68-1

分子式

C27H33N5O4

主要靶点

Others

仅限科研使用

Cat No : CM03012

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Synonyms

验证数据展示

  • CAS No.: 1311174-68-1

    PH-002
    CAS#: 1311174-68-1

产品信息

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells. It also could rescue impairments of mitochondrial motility and neurite outgrowth.

CAS号 1311174-68-1
分子式 C27H33N5O4
主要靶点 Others
主要通路 其他
分子量 491.58
纯度 99.36%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

Apo E4 in FRET:116 nM

体内活性

PH-002 (100 nM) enhances dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons). PH-002 is also shown to enhance COX1 levels in primary neurons from the NSE-apoE4 transgenic mouse cortex and hippocampus. COX1 levels are increased by ~60% after 4 days of treatment with PH-002 (200 nM) [2].

体外活性

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells (IC50: 116 nM in FRET)[1].

溶解度

DMSO:75 mg/mL (152.57 mM)

参考文献

1.Brodbeck J, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13;286(19):17217-26.
2.Chen HK, et al. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. J Biol Chem. 2012 Feb 17;287(8):5253-66.

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