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Phenformin hydrochloride

Phenformin hydrochloride (Phenformin HCl) 是一种具有抗高血糖活性的双胍类抗糖尿病药物，能够使 AMPK 活化。

CAS号

834-28-6

分子式

C10H16ClN5

主要靶点

Autophagy|AMPK|Potassium Channel

仅限科研使用

Cat No : CM00432

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Synonyms

盐酸苯乙福明|Phenethylbiguanide hydrochloride|Phenformin HCl

验证数据展示

  • CAS No.: 834-28-6

    Phenformin hydrochloride
    CAS#: 834-28-6

产品信息

Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.

CAS号 834-28-6
分子式 C10H16ClN5
主要靶点 Autophagy|AMPK|Potassium Channel
主要通路 自噬|PI3K/Akt/mTOR信号通路|表观遗传|离子通道
分子量 241.72
纯度 99.15%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 盐酸苯乙福明|Phenethylbiguanide hydrochloride|Phenformin HCl

体内活性

在H441细胞中,Phenformin能够增加AMPK活性,同时降低基础离子的转运。在分离的心脏中,Phenformin 增加AMPK活性和磷酸化。在LKB1缺陷型NSCLC细胞系中,Phenformin 能够显著诱导凋亡。

体外活性

在小鼠的肺脏和肺肿瘤中,Phenformin能够上调P-eIF2α和其靶标BiP/ Grp78的水平.

溶解度

DMSO:45 mg/mL (186.2 mM),H2O:44 mg/mL (182 mM),Ethanol:10 mg/mL (41.4 mM)

参考文献

1.Sakamoto K, et al. Am J Physiol Endocrinol Metab, 2004, 287(2), E310-317.
2.Zhang L, et al. Am J Physiol Heart Circ Physiol, 2007, 293(1), H457-466.
3.Moreira AL, et al. J Exp Med, 1993, 177(6), 1675-1680.
4.Woollhead AM, et al. J Physiol, 2005, 566(Pt 3), 781-792.
5.Dilman VM, et al. Arch Geschwulstforsch, 1978, 48(1), 1-8.

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