验证数据展示
发表文章中的应用
| KD/KO | See 1 publications below |
| WB | See 1 publications below |
产品信息
18798-1-AP targets PLA2R1 in WB, ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB |
| 经测试反应性 | human |
| 文献引用反应性 | human |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | phospholipase A2 receptor 1, 180kDa |
| 别名 | CLEC13C, M type receptor, PLA2 R, PLA2G1R, PLA2IR, PLA2R, PLA2R1, Soluble PLA2 R, Soluble PLA2R |
| 计算分子量 | 168 kDa |
| GenBank蛋白编号 | BC144631 |
| 基因名称 | PLA2R1 |
| Gene ID (NCBI) | 22925 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q13018 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Secretory phospholipase A2 (sPLA2) are implicated in a number of crucial physiological and pathological processes in mammals. Different types of membrane receptors for sPLA2s have been identified. The M-type receptor, PLA2R1 (phospholipase A2 receptor 1, 180 kDa), is a type I transmembrane glycoprotein containing extracellularly a cysteine-rich domain, a fibronectin type II domain and eight carbohydrate-recognition domains. It is a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. It is also able to bind to snake PA2-like toxins. PLA2R1 may be involved in responses in proinflammatory cytokine productions during endotoxic shock. It also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. It has been recently shown that PLA2R1 is the major target antigen in idiopathic membranous nephropathy (iMN). Patients with iMN have antibodies against a conformation-dependent epitope in PLA2R1.
