PMS1 Polyclonal antibody
PMS1 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
ELISA and More (2)
Conjugate
Unconjugated
验证数据展示
发表文章中的应用
| WB | See 1 publications below |
| IHC | See 2 publications below |
产品信息
10859-1-AP targets PMS1 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Applications | ELISA Application Description |
| Cited Applications | WB, IHC |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human |
| Immunogen | PMS1 fusion protein Ag1158 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) |
| Synonyms | HNPCC3, hPMS1, PMS1, PMS1 protein homolog 1, PMSL1 |
| Calculated Molecular Weight | 106 kDa |
| GenBank Accession Number | BC008410 |
| Gene Symbol | PMS1 |
| Gene ID (NCBI) | 5378 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P54277 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
The multiple eukaryotic homologs of the bacterial MutL mismatch repair protein are implicated along with MutS homologs in maintaining genomic integrity during DNA replication and recombination [PMID:16612326]. DNA mismatch repair (MMR) corrects replication errors that would otherwise lead to mutations and, potentially, various forms of cancer. Among several proteins required for eukaryotic MMR, MutLα is a heterodimer comprised of Mlh1 and PMS1 [PMID:19115045]. PMS1 contains an N-terminal domain (NTD) and C-terminal domain (CTD) ,which separated by a flexible linker. Dimerization occurs between the CTDs and the CTD of PMS1 houses a strand-specific endonuclease that is necessary for MMR [PMID:17951253].
发表文章
| Species | Application | Title |
|---|---|---|
Breast Cancer Res Tumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families. | ||