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PMS2 Monoclonal antibody, PBS Only

PMS2 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human, rat, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1G4E6

Cat no : 66075-1-PBS

Print datasheet

Synonyms

HNPCC4, PMS1 protein homolog 2, PMS2, PMS2CL, PMSL2

验证数据展示

  • WB analysis of HeLa using 66075-1-Ig (same clone as 66075-1-PBS)

    WB analysis of HeLa using 66075-1-Ig (same clone as 66075-1-PBS)

    Vairous cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

  • WB analysis of A431 using 66075-1-Ig (same clone as 66075-1-PBS)

    WB analysis of A431 using 66075-1-Ig (same clone as 66075-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 66075-1-Ig (PMS2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66075-1-PBS in a different storage buffer formulation.

产品信息

66075-1-PBS targets PMS2 in WB, Indirect ELISA applications and shows reactivity with human, rat, mouse samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human, rat, mouse
Immunogen PMS2 fusion protein Ag12661 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
Synonyms HNPCC4, PMS1 protein homolog 2, PMS2, PMS2CL, PMSL2
Calculated Molecular Weight 862 aa, 96 kDa
Observed Molecular Weight 100 kDa
GenBank Accession NumberBC093921
Gene Symbol PMS2
Gene ID (NCBI) 5395
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP54278
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PMS2, also named as PMSL2, belongs to the DNA mismatch repair mutL/hexB family. It is a component of the post-replicative DNA mismatch repair system (MMR). It heterodimerizes with MLH1 to form MutL alpha. MulL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. It also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. (PMID: 16873062, PMID: 18206974) Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS).