验证数据展示
产品信息
51050-1-AP targets PNRC2 in WB, IHC, ChIP, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IHC, ChIP |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human |
| 免疫原 | PNRC2 fusion protein Ag0099 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | proline-rich nuclear receptor coactivator 2 |
| 别名 | Proline-rich nuclear receptor coactivator 2, HSPC208 |
| 计算分子量 | 16 kDa |
| 观测分子量 | 25 kDa |
| GenBank蛋白编号 | BC001959 |
| 基因名称 | PNRC2 |
| Gene ID (NCBI) | 55629 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9NPJ4 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
PNRC2 belongs to the PNRC family and PNRC2 subfamily. It is Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. It is required for UPF1/RENT1 localization to the P-body. PNRC2 also acts as a nuclear receptor coactivator. It may play a role in controlling the energy balance between energy storage and energy expenditure. (PMID:19150429) PNRC2 functions as a coactivator of several nuclear receptors, including ERRa, and participates in the activation of aromatase in conjunction with ERRa. Growth factor signaling promotes PELP1 recruitment to the aromatase chromatin and its formation of a complex with ERRa and PNRC2.(PMID:18079323)