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PPP1R3C Polyclonal antibody, PBS Only

PPP1R3C Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 29424-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 29424-1-AP (same clone as 29424-1-PBS)

    WB analysis using 29424-1-AP (same clone as 29424-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 29424-1-AP (PPP1R3C antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29424-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 29424-1-AP (same clone as 29424-1-PBS)

    IHC staining of human colon cancer using 29424-1-AP (same clone as 29424-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 29424-1-AP (PPP1R3C antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29424-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 29424-1-AP (same clone as 29424-1-PBS)

    IHC staining of human colon cancer using 29424-1-AP (same clone as 29424-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 29424-1-AP (PPP1R3C antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29424-1-PBS in a different storage buffer formulation.

产品信息

29424-1-PBS targets PPP1R3C in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen PPP1R3C fusion protein Ag30280 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name protein phosphatase 1, regulatory (inhibitor) subunit 3C
Synonyms
Calculated Molecular Weight 317 aa, 36 kDa
GenBank Accession NumberBC012625
Gene Symbol PPP1R3C
Gene ID (NCBI) 5507
RRIDAB_2918304
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9UQK1
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

• Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) is an enzyme that binds to protein phosphatase-1 (PP1) as a regulator. The central role of PPP1R3C is associated with glycogenesis and the overexpression of this gene increases glycogen storage. The cellular glycogen level is suppressed when PPP1R3C is knocked-down. PPP1R3C induces glycogen accumulation via HIF1 α during hypoxia and it is hypermethylated in melanoma (PMID: 25846879). Overexpression of PPP1R3C increased hepatic gluconeogenesis in vitro and in vivo while knockdown of PPP1R3C showed an opposite result (PMID: 31181215).