验证数据展示
产品信息
66820-1-PBS targets PRDX1 in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Applications | WB, IHC, IF-P, Indirect ELISA Application Description |
Tested Reactivity | human, mouse, rat |
Immunogen | PRDX1 fusion protein Ag8821 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | peroxiredoxin 1 |
Synonyms | PAG, NKEF-A, Natural killer cell-enhancing factor A, MSP23, EC:1.11.1.24 |
Calculated Molecular Weight | 199 aa, 22 kDa |
Observed Molecular Weight | 23 kDa |
GenBank Accession Number | BC007063 |
Gene Symbol | PRDX1 |
Gene ID (NCBI) | 5052 |
RRID | AB_2882163 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q06830 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
PRDX1(Peroxiredoxin-1), also named as PAGA, PAGB, TDPX2, PAG or NKEF-A, belongs to the ahpC/TSA family. PRDX1 is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2 ((PMID: 9497357)). It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. PRDX1 can form a dimer, and also can be phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity (PMID: 22583657, 11986303).