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验证数据展示

  • WB analysis of mouse pancreas using 11493-1-AP (same clone as 11493-1-PBS)

    WB analysis of mouse pancreas using 11493-1-AP (same clone as 11493-1-PBS)

    mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 11493-1-AP (PTPMT1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

  • IHC staining of human pancreas cancer using 11493-1-AP (same clone as 11493-1-PBS)

    IHC staining of human pancreas cancer using 11493-1-AP (same clone as 11493-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer using 11493-1-AP (PTPMT1 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 11493-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

PTPMT1 Polyclonal antibody, PBS Only

PTPMT1 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 11493-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

11493-1-PBS targets PTPMT1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 PTPMT1 fusion protein Ag2063 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 protein tyrosine phosphatase, mitochondrial 1
别名
计算分子量 201 aa, 23 kDa
观测分子量 21-23 kDa
GenBank蛋白编号BC020242
基因名称 PTPMT1
Gene ID (NCBI) 114971
RRIDAB_2237967
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8WUK0
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Protein Tyrosine Phosphatase localized to the Mitochondrial 1 (PTPMT1) is a highly conserved, dual-specific phosphatase that resides on the matrix-facing side of the inner mitochondrial membrane (IMM). PTPMT1 is a mitochondrial phosphatase and a vital regulator of mitochondrial activities. Current work points to roles for PTPMT1 in the regulation of mitochondrial respiration, dynamics, and ultrastructure through the modulation of pyruvate importation, the tuning of TCA cycle activity, and the synthesis of cardiolipin. PTPMT1 is highly expressed in pancreatic b cells, whose mitochondria have the important function of coupling glucose metabolism to the secretion of insulin. (PMID: 16337125, PMID: 16061174, PMID: 33335799)