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验证数据展示

  • WB analysis using 27941-1-AP

    WB analysis using 27941-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 27941-1-AP (PTPRD antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours.

  • WB analysis using 27941-1-AP

    WB analysis using 27941-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 27941-1-AP (PTPRD antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

  • IHC staining of human liver using 27941-1-AP

    IHC staining of human liver using 27941-1-AP

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 27941-1-AP (PTPRD antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • IHC staining of human liver using 27941-1-AP

    IHC staining of human liver using 27941-1-AP

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 27941-1-AP (PTPRD antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

PTPRD Polyclonal antibody

PTPRD Polyclonal Antibody for WB, IHC, ELISA
Cat No. 27941-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, ELISA

别名

PTPD, Protein-tyrosine phosphatase delta, HPTPD, HPTP DELTA, HPTP

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive WB detected inHuH-7 cells, human placenta tissue, mouse liver tissue, rat liver tissue
Positive IHC detected inhuman liver tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:1000-1:5000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

27941-1-AP targets PTPRD in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 PTPRD fusion protein Ag27689 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 protein tyrosine phosphatase, receptor type, D
别名 PTPD, Protein-tyrosine phosphatase delta, HPTPD, HPTP DELTA, HPTP
计算分子量 1912 aa, 215 kDa
观测分子量75 kDa, 175 kDa
GenBank蛋白编号BC106714
基因名称 PTPRD
Gene ID (NCBI) 5789
RRIDAB_3086013
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDP23468
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

PTPRD is a receptor-type protein tyrosine phosphatase that plays significant roles in various biological processes, including cell adhesion, synaptic function, and signal transduction. PTPRD is highly expressed in the brain, followed by the kidney, ovary, placenta, and intestine. Within the brain, it is found in specific regions, suggesting a role in neurological functions. PTPRD has emerged as a potential therapeutic target for various brain phenotypes and disorders. Its genetic variations have been associated with nervous system phenotypes, and the discovery of the first small molecule inhibitor of PTPRD phosphatase has opened new avenues for therapeutic intervention in addiction and possibly other PTPRD-associated disorders. Additionally, PTPRD is considered a tumor-suppressor gene that is down-regulated in hepatocellular carcinoma, suggesting its role in cancer progression and potential as a therapeutic target. The protein can recognize 175 kDa full length and 75 kDa mature cleavage product (PMID: 19074898, PMID: 25113440).

实验方案

Product Specific Protocols
WB protocol for PTPRD antibody 27941-1-APDownload protocol
IHC protocol for PTPRD antibody 27941-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols