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Phospho-APP (Thr668) Polyclonal antibody, PBS Only

Phospho-APP (Thr668) Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 28788-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 28788-1-AP (same clone as 28788-1-PBS)

    WB analysis using 28788-1-AP (same clone as 28788-1-PBS)

    Non-treated and nocodazole treated SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 28788-1-AP (Phospho-APP (Thr668) antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28788-1-PBS in a different storage buffer formulation.

产品信息

28788-1-PBS targets Phospho-APP (Thr668) in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name amyloid beta (A4) precursor protein
Synonyms
Observed Molecular Weight110 kDa
GenBank Accession NumberBC065529
Gene Symbol APP
Gene ID (NCBI) 351
RRIDAB_2918202
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP05067
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Amyloid precursor protein (APP) is a membrane-spanning protein with a large extracellular domain and a much smaller intracellular domain(PMID: 25719338). APP is expressed in many tissues and concentrated in the synapses of neurons. The molecular weight of APP is 100-140 kDa due to the existence of several isoforms. The phosphorylation of APP at Thr668 is involved in the pathogenesis of Alzheimer's disease (AD). The Phospho-APP Thr668 form is neuron‐specific, highly expressed in dystrophic neurites and amyloid plaques of Alzheimer disease, and induces neurodegeneration(PMID: 27076121).