Phospho-P62/SQSTM1 (Ser349) Polyclonal antibody

Phospho-P62/SQSTM1 (Ser349) Polyclonal Antibody for WB, ELISA
Cat No. 29503-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse and More (1)

应用

WB, ELISA and More (1)

p p62 (Ser349), p p62 Ser349, p P62,SQSTM1, p P62,SQSTM1 (Ser349), p P62,SQSTM1 Ser349

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inMG132 treated HeLa cells
Planning an IHC experiment? We recommend our IHCeasy P62,SQSTM1 Ready-To-Use IHC Kit. P62,SQSTM1 primary antibody included.

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:2000-1:16000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

29503-1-AP targets Phospho-P62/SQSTM1 (Ser349) in WB, IF, ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, ELISA Application Description
文献引用应用WB, IF
经测试反应性 human, mouse
文献引用反应性human, mouse, rat
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 sequestosome 1
别名 p p62 (Ser349), p p62 Ser349, p P62,SQSTM1, p P62,SQSTM1 (Ser349), p P62,SQSTM1 Ser349
计算分子量 48 kDa
观测分子量 62 kDa
GenBank蛋白编号BC017222
基因名称 P62/SQSTM1
Gene ID (NCBI) 8878
RRIDAB_2923592
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ13501
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Sequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis. It functions as a bridge between polyubiquitinated cargo and autophagosomes (PMID:16286508). SQSTM1 is at the cross-roads of several signaling pathways including Keap1-Nrf2 pathway , NFκB pathway , NFE2L2/NRF2 pathway , mTOR pathway and Wnt pathway. Phosphorylation and/or de-phosphorylation of p62-Ser349 may participate in the regulation of both selective autophagy and oxidative stress response (PMID: 33397898).

实验方案

Product Specific Protocols
WB protocol for Phospho-P62/SQSTM1 (Ser349) antibody 29503-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
human,mouseWB

Cell Death Differ

SLC15A3 plays a crucial role in pulmonary fibrosis by regulating macrophage oxidative stress

Authors - Jun Luo
mouseWB

Chin Med

NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin

Authors - Qian Zeng
ratWB

J Med Chem

A Lysosome-Targeting hNEU1 Inhibitor Treats Myocardial Infarction: A Potential Therapeutic Breakthrough

Authors - Wen Zhou
mouseIF

Cell Death Dis

TMEM232 is required for the formation of sperm flagellum and male fertility in mice

Authors - Xinying Cai
humanWB

J Biol Chem

Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation

Authors - Hongrui Wang
humanWB

J Virol

The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy

Authors - Sen Jiang
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