Phospho-TDP43 (Ser409/410) Polyclonal antibody, PBS Only
Phospho-TDP43 (Ser409/410) Polyclonal Antibody for WB, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
验证数据展示
Planning an IHC experiment? We recommend our IHCeasy TDP-43 Ready-To-Use IHC Kit. TDP-43 primary antibody included.
产品信息
22309-1-PBS targets Phospho-TDP43 (Ser409/410) in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Applications | WB, Indirect ELISA Application Description |
Tested Reactivity | human, mouse |
Immunogen | Peptide 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | TAR DNA binding protein |
Synonyms | TDP 43, TARDBP, TDP43, TDP-43, TAR DNA-binding protein 43 |
Calculated Molecular Weight | 43 kDa |
Observed Molecular Weight | 40-50 kDa, 25-35 kDa |
GenBank Accession Number | NM_007375 |
Gene Symbol | TDP-43 |
Gene ID (NCBI) | 23435 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q13148 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Transactivation response (TAR) DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43) was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U). Various forms of TDP-43 exist, including 18-35 kDa of cleaved C-terminal fragments, 45-50 kDa phospho-protein, 55 kDa glycosylated form, 75 kDa hyperphosphorylated form, and 90-300 kDa cross-linked form. (PMID: 17023659,19823856, 21666678, 22193176).22309-1-AP is a rabbit polyclonal antibody recognizing TDP-43 only when phosphorylated at 409/410. Immunohistochemical analyses using this antibody only stain the insoluble inclusions in pathologic tissues without normal diffuse nuclear staining.