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Piperlongumine

Piperlongumine (Piplartine) 是一种来自 Piper longum L. 的天然生物碱，具有抗炎、抗菌、抗血管生成、抗氧化、抗肿瘤和抗糖尿病等活性。它选择性地杀死癌细胞并增强活性氧的水平。它具有抗心肌纤维化的作用，通过抑制 ERK1/2 信号通路抑制肌成纤维细胞的转化。

CAS号

20069-09-4

分子式

C17H19NO5

主要靶点

Ferroptosis|Reactive Oxygen Species|Autophagy|Antibacterial|ERK|Apoptosis|ROS

仅限科研使用

Cat No : CM00445

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Synonyms

PPLGM|荜茇酰胺|Piplartine

验证数据展示

  • CAS No.: 20069-09-4

    Piperlongumine
    CAS#: 20069-09-4

产品信息

Piperlongumine is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).

CAS号 20069-09-4
分子式 C17H19NO5
主要靶点 Ferroptosis|Reactive Oxygen Species|Autophagy|Antibacterial|ERK|Apoptosis|ROS
主要通路 NF-κB信号通路|自噬|免疫与炎症|MAPK信号通路|微生物学|代谢|凋亡
分子量 317.34
纯度 99.89%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 PPLGM|荜茇酰胺|Piplartine

体内活性

Piperlongumine (50 mg/kg i.p.) causes in vivo growth inhibition of tumor cells without leading to major changes in the biochemical, hematological and histopathological parameters. [4]

体外活性

Piperlongumine is a known ROS inducer which could induce pancreatic cancer cell death in cell culture[1] As a thromboxane A(2) receptor antagonist, Piperlongumine inhibits platelet aggregation. [2] Piperlongumine also promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death. [3]

溶解度

DMSO:31.7 mg/mL (100 mM)

细胞实验

MCF-7 and 786-O cells are incubated with various PL concentrations for 48h. Cell proliferation is analysed by CellTiter Blue assay. Effective doses (ED) are calculated using XLift, Microsoft Excel add-in. (Only for Reference)

参考文献

1.Dhillon H, et al. Toxicol Rep. 2014, 1:309-318.
2.Iwashita M, et al. Eur J Pharmacol. 2007, 570(1-3), 38-42.
3.Ryu J, et al. Nat Prod Res. 2014, 28(22), 2040-2043.
4.Bezerra DP, et al. J Appl Toxicol. 2008, 28(5), 599-607.
5.Zou P, et al. Cancer Lett. 2016, 375(1):114-26.
6.Wu X, e,t al. Piperlongumine inhibits angiotensin II-induced extracellular matrix expression in cardiac fibroblasts. J Cell Biochem. 2018 Dec;119(12):10358-10364

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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