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Prealbumin/transthyretin Monoclonal antibody, PBS Only

Prealbumin/transthyretin Monoclonal Antibody for Indirect ELISA, IHC, WB

Host / Isotype

Mouse / IgG2a

Reactivity

mouse, human

Applications

Indirect ELISA, IHC, WB

Conjugate

Unconjugated

CloneNo.

1H8C4

Cat no : 66108-1-PBS

Print datasheet

Synonyms

Prealbumin, transthyretin, TTR, TBPA, PALB

验证数据展示

  • WB analysis of human brain using 66108-1-Ig (same clone as 66108-1-PBS)

    WB analysis of human brain using 66108-1-Ig (same clone as 66108-1-PBS)

    human brain tissue were subjected to SDS PAGE followed by western blot with 66108-1-Ig (Prealbumin/transthyretin antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66108-1-PBS in a different storage buffer formulation.

  • FC experiment of PC-12 using 66108-1-Ig (same clone as 66108-1-PBS)

    FC experiment of PC-12 using 66108-1-Ig (same clone as 66108-1-PBS)

    1X10^6 PC-12 cells were intracellularly stained with 0.4 ug Anti-Human Prealbumin/transthyretin (66108-1-Ig, Clone:1H8C4) and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) at dilution 1:1000 (red), or 0.4 ug Control Antibody. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 66108-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 66108-1-Ig (same clone as 66108-1-PBS)

    IHC staining of human liver using 66108-1-Ig (same clone as 66108-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 66108-1-Ig (Prealbumin/transthyretin antibody at dilution of 1:50. This data was developed using the same antibody clone with 66108-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with TTR antibody included
Planning an IHC experiment? We recommend our IHCeasy TTR Ready-To-Use IHC Kit. TTR primary antibody included.

产品信息

66108-1-PBS targets Prealbumin/transthyretin in Indirect ELISA, IHC, WB applications and shows reactivity with mouse, human samples.

Tested Applications Indirect ELISA, IHC, WB Application Description
Tested Reactivity mouse, human
Immunogen Prealbumin/transthyretin fusion protein Ag19232 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name transthyretin
Synonyms Prealbumin, transthyretin, TTR, TBPA, PALB
Calculated Molecular Weight 147 aa, 16 kDa
Observed Molecular Weight 14-16 kDa, 28-33 kDa
GenBank Accession NumberBC020791
Gene Symbol TTR
Gene ID (NCBI) 7276
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP02766
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Transthyretin (TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition (amyloidosis). Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR),hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) and carpal tunnel syndrome type 1 (CTS1). In addition, positive immunostaining for TTR has been reported as a sensitive diagnostic marker of choroid plexus tumors. TTR can be expressed as monomer (14-16 kDa), dimmer (28-33 kDa), or tetramer around 55-60 kDa. (PMID: 22103483)