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验证数据展示

  • WB analysis of human brain using 66108-1-Ig (same clone as 66108-1-PBS)

    WB analysis of human brain using 66108-1-Ig (same clone as 66108-1-PBS)

    human brain tissue were subjected to SDS PAGE followed by western blot with 66108-1-Ig (Prealbumin/transthyretin antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66108-1-PBS in a different storage buffer formulation.

  • FC experiment of PC-12 using 66108-1-Ig (same clone as 66108-1-PBS)

    FC experiment of PC-12 using 66108-1-Ig (same clone as 66108-1-PBS)

    1X10^6 PC-12 cells were intracellularly stained with 0.4 ug Anti-Human Prealbumin/transthyretin (66108-1-Ig, Clone:1H8C4) and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) at dilution 1:1000 (red), or 0.4 ug Control Antibody. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 66108-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 66108-1-Ig (same clone as 66108-1-PBS)

    IHC staining of human liver using 66108-1-Ig (same clone as 66108-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 66108-1-Ig (Prealbumin/transthyretin antibody at dilution of 1:50. This data was developed using the same antibody clone with 66108-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with TTR antibody included

Prealbumin/transthyretin Monoclonal antibody, PBS Only

Prealbumin/transthyretin Monoclonal Antibody for Indirect ELISA, IHC, WB
Cat No. 66108-1-PBS

产品说明书

CloneNo. 1H8C4

宿主/亚型

Mouse / IgG2a

种属反应性

mouse, human

应用

Indirect ELISA, IHC, WB

别名

Prealbumin, transthyretin, TTR, TBPA, PALB

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy TTR Ready-To-Use IHC Kit. TTR primary antibody included.

产品信息

66108-1-PBS targets Prealbumin/transthyretin in Indirect ELISA, IHC, WB applications and shows reactivity with mouse, human samples.

经测试应用 Indirect ELISA, IHC, WB Application Description
经测试反应性 mouse, human
免疫原 Prealbumin/transthyretin fusion protein Ag19232 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 transthyretin
别名 Prealbumin, transthyretin, TTR, TBPA, PALB
计算分子量 147 aa, 16 kDa
观测分子量 14-16 kDa, 28-33 kDa
GenBank蛋白编号BC020791
基因名称 TTR
Gene ID (NCBI) 7276
RRIDAB_2881507
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP02766
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Transthyretin (TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition (amyloidosis). Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR),hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) and carpal tunnel syndrome type 1 (CTS1). In addition, positive immunostaining for TTR has been reported as a sensitive diagnostic marker of choroid plexus tumors. TTR can be expressed as monomer (14-16 kDa), dimmer (28-33 kDa), or tetramer around 55-60 kDa. (PMID: 22103483)