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Prochlorperazine Maleate

Prochlorperazine Maleate (Capazine) 是一种吩噻嗪类抗精神病药，主要用于治疗恶心、呕吐和眩晕。它比氯丙嗪更容易引起锥体外系疾病。

CAS号

84-02-6

分子式

C28H32ClN3O8S

主要靶点

Dopamine Receptor

仅限科研使用

Cat No : CM03777

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Synonyms

Prochlorperazin|Prochlorperazine dimaleate salt|Capazine|Stemetil|Compazine|丙氯拉嗪

验证数据展示

  • CAS No.: 84-02-6

    Prochlorperazine Maleate
    CAS#: 84-02-6

产品信息

Prochlorperazine maleate is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS.

CAS号 84-02-6
分子式 C28H32ClN3O8S
主要靶点 Dopamine Receptor
主要通路 G蛋白偶联受体|神经科学
分子量 606.09
纯度 99.99%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Prochlorperazin|Prochlorperazine dimaleate salt|Capazine|Stemetil|Compazine|丙氯拉嗪

体内活性

Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole[1].

体外活性

Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy[2].

溶解度

H2O:<1 mg/mL,DMSO:15.2 mg/mL (25 mM),Ethanol:2 mg/mL (3.3 mM),warmed

细胞实验

Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR.(Only for Reference)

参考文献

1.Ghelardini C, et al. Pharmacol Res. 20014, 50(3):351-358.
2.Huang L, et al. PLoS One. 2011, 6(7):e22274.
3.Dong L, Shen S, Chen W, et al. Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation[J]. Journal of chemical information and modeling. 2019, 59(10): 4374-4382.

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