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  • Featured Product
  • KD/KO Validated

Progranulin/PGRN Polyclonal antibody, PBS Only

Progranulin/PGRN Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 18410-1-PBS

Print datasheet

Synonyms

验证数据展示

  • WB analysis using 18410-1-AP (same clone as 18410-1-PBS)

    WB analysis using 18410-1-AP (same clone as 18410-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 18410-1-AP (Granulin antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18410-1-PBS in a different storage buffer formulation.

  • IHC staining of human pancreas cancer using 18410-1-AP (same clone as 18410-1-PBS)

    IHC staining of human pancreas cancer using 18410-1-AP (same clone as 18410-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 18410-1-AP (Granulin antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18410-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with GRN antibody included
  • IHC staining of human pancreas cancer using 18410-1-AP (same clone as 18410-1-PBS)

    IHC staining of human pancreas cancer using 18410-1-AP (same clone as 18410-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 18410-1-AP (Granulin antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18410-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with GRN antibody included
Planning an IHC experiment? We recommend our IHCeasy GRN Ready-To-Use IHC Kit. GRN primary antibody included.

产品信息

18410-1-PBS targets Progranulin/PGRN in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen Progranulin/PGRN fusion protein Ag13178 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name granulin
Synonyms
Calculated Molecular Weight 64 kDa
Observed Molecular Weight 60-70 kDa
GenBank Accession NumberBC000324
Gene Symbol Granulin
Gene ID (NCBI) 2896
RRIDAB_10598161
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP28799
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

GRN, also known as PGRN or PCDGF, is a cysteine-rich protein of 68.5 kDa that is typically secreted into a highly glycosylated 88 kDa form. PGRN is a unique growth factor that plays an important role in cutaneous wound healing. It has an anti-inflammatory effect and promotes cell proliferation. When PCDGF is degraded to several 6-25 kDa fragments, called granulins (GRNs) by neutrophil proteases, a pro-inflammatory reaction occurs. PGRN is widely expressed, particularly in epithelial cells, immune cells, neurons, and chondrocytes. High levels of PGRN expression have been reported in human cancers, and its expression is closely correlated with the development and metastasis of several cancers. The recent discovery that mutations in the gene encoding for pro-granulin (GRN) cause frontotemporal lobar degeneration (FTLD), and other neurodegenerative diseases leading to dementia, has brought renewed interest in progranulin and its functions in the central nervous system.