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Pyrvinium pamoate

Pyrvinium pamoate (Pyrvinium embonate) 是一种古老的驱虫药，用于治疗蛲虫病，由于其在某些类型的癌症中抑制 Wnt/β-catenin 通路，它作为抗癌药物再次引起人们的关注。

CAS号

3546-41-6

分子式

C26H28N3 . 1/2 C23H14O6

主要靶点

Wnt/beta-catenin

仅限科研使用

Cat No : CM01413

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Synonyms

Pyrvinium embonate|扑蛲灵

验证数据展示

  • CAS No.: 3546-41-6

    Pyrvinium pamoate
    CAS#: 3546-41-6

产品信息

Pyrvinium pamoate is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt/β-catenin pathway in some types of cancer.

CAS号 3546-41-6
分子式 C26H28N3 . 1/2 C23H14O6
主要靶点 Wnt/beta-catenin
主要通路 干细胞|细胞骨架
分子量 575.7
纯度 98.43%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Pyrvinium embonate|扑蛲灵

体外活性

Pyrvinium pamoate treatment repressed the phosphorylation of GSK3β at S9 which might be mediated by AKT, and decreased the protein levels of β-catenin and its downstream targets (c-Myc, cyclin D1). Pyrvinium pamoate remarkably inhibited cell viability and colony formation ability. Treatment with pyrvinium pamoate induced intrinsic pathway-dependent apoptosis accompanied with a decline of anti-apoptotic XIAP and Survivin, and an overt increase of pro-apoptotic Bax. In addition, pyrvinium pamoate significantly inhibited the migration and invasion in vitro[1].

溶解度

DMSO:12 mg/mL (20.84 mM)

参考文献

1.Zheng L , Liu Y , Pan J . Inhibitory effect of pyrvinium pamoate on uveal melanoma cells involves blocking of Wnt/β-catenin pathway[J].2017(49):898.
2.Xu F , Zhu Y , Lu Y , et al. Anthelmintic pyrvinium pamoate blocks Wnt/β-catenin and induces apoptosis in multiple myeloma cells[J]. Oncology Letters, 2018.

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