• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

RBN-3143

RBN-3143 是有效的 NAD+ 竞争性催化 PARP14 抑制剂 (IC50= 4 nM)。 RBN-3143 可以抑制 PARP14 介导的 ADP-核糖基化，并稳定细胞系中的 PARP14。 RBN-3143 可用于肺部炎症研究。

CAS号

2360853-16-1

分子式

C22H28FN3O4S

主要靶点

PARP

仅限科研使用

Cat No : CM16004

Print datasheet

Synonyms

验证数据展示

  • CAS No.: 2360853-16-1

    RBN-3143
    CAS#: 2360853-16-1

产品信息

RBN-3143 is a potent and inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM). RBN-3143 inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines. RBN-3143 exhibits research potential of lung inflammation.

CAS号 2360853-16-1
分子式 C22H28FN3O4S
主要靶点 PARP
主要通路 DNA损伤和修复|表观遗传
分子量 449.54
纯度 98.64%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
别名

靶点活性

PARP14:4 nM

体内活性

RBN-3143 (5 μg; Intranasal administration) can improve the steroid resistant asthma mouse model [1].

溶解度

DMSO:11.2 mg/mL (25.0 mM),ultrasonic and warming and heat to 80°C

参考文献

1.Niepel M, et, al. The PARP14 inhibitor RBN-3143 suppresses lung inflammation in preclinical models. European Respiratory Journal 2022 60: 4642.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2