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RGFP966 (E-isomer)

RGFP966 是一种 HDAC3 抑制剂，IC50 为 0.08 μM，比其他 HDAC 选择性高 200 倍以上。

CAS号

1396841-57-8

分子式

C21H19FN4O

主要靶点

HDAC

仅限科研使用

Cat No : CM04430

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Synonyms

验证数据展示

  • CAS No.: 1396841-57-8

    RGFP966 (E-isomer)
    CAS#: 1396841-57-8

产品信息

RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.

CAS号 1396841-57-8
分子式 C21H19FN4O
主要靶点 HDAC
主要通路 DNA损伤和修复|表观遗传
分子量 362.4
纯度 99.10%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

HDAC3:0.08 μM

体外活性

In mammals, halofuginone at 10 ng/ml down-regulates Smad3, blocking TGF-β signaling and preventing both the differentiation of fibroblasts to myofibroblasts and the transitioning of epithelial cells to mesenchymal cells[2].

溶解度

DMSO:67 mg/mL (184.9 mM),H2O:<1 mg/mL,Ethanol:<1 mg/mL

参考文献

1.Malvaez M, et al. PNAS, 2013, 110(7), 2647-2652.
2.Wells CE, et al. PLoS One, 2013, 8(7), e68915.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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