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RGS3 Monoclonal antibody, PBS Only

RGS3 Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

1D6A3

Cat no : 66790-1-PBS

Print datasheet

Synonyms

C2PA, FLJ20370, FLJ31516, FLJ90496, PDZ RGS3, RGP3, RGS3

验证数据展示

  • WB analysis of Jurkat using 66790-1-Ig (same clone as 66790-1-PBS)

    WB analysis of Jurkat using 66790-1-Ig (same clone as 66790-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 66790-1-Ig (RGS3 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66790-1-PBS in a different storage buffer formulation.

产品信息

66790-1-PBS targets RGS3 in WB, ELISA applications and shows reactivity with Human samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity Human
Immunogen RGS3 fusion protein Ag3177 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name regulator of G-protein signaling 3
Synonyms C2PA, FLJ20370, FLJ31516, FLJ90496, PDZ RGS3, RGP3, RGS3
Calculated Molecular Weight 1198 aa, 132 kDa
Observed Molecular Weight 140 kDa
GenBank Accession NumberBC018072
Gene Symbol RGS3
Gene ID (NCBI) 5998
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP49796
Storage Buffer PBS only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

RGS3 belongs to a family of proteins which share the core regulator of G-protein signalling (RGS) domain and function as GTPase-activating proteins (GAPs) for the α subunit of heterotrimeric G-proteins. RGS3 has been reported to inhibit the Gai-and Gaq-mediated signaling pathways in the cardiovascular system, including those acting via the cardiovascular signaling molecules angiotensin II (Ang II), sphingosine 1-phosphate and endothelin-1. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear.