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RIPK1-IN-4

RIPK1-IN-4 是有效的 II 型激酶受体相互作用蛋白1 (RIP1) 激酶抑制剂，并且与 DL1-out 无活性形式的 RIP1 结合。RIPK1-IN-4抑制 RIP1 和 ADP-Glo 激酶，IC50 分别是 16 nM 和 10 nM。

CAS号

1481641-08-0

分子式

C23H23N5O2

主要靶点

RIP kinase

仅限科研使用

Cat No : CM18665

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Synonyms

验证数据展示

  • CAS No.: 1481641-08-0

    RIPK1-IN-4
    CAS#: 1481641-08-0

产品信息

RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase).

CAS号 1481641-08-0
分子式 C23H23N5O2
主要靶点 RIP kinase
主要通路 NF-κB信号通路|凋亡
分子量 401.46
纯度 99.66%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

ADP-Glo:10 nM |RIP1:16 nM

溶解度

DMSO:225.0 mg/mL (560.5 mM),Sonification is recommended.

参考文献

1.Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43.

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