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RIPK1-IN-7

RIPK1-IN-7 是一种选择性有效的 RIPK1 抑制剂，Kd 值为 4 nM，IC50值为 11 nM。在实验性 B16 黑色素瘤肺转移模型中表现出优异的抗转移活性。

CAS号

2300982-44-7

分子式

C25H22F3N5O2

主要靶点

RIP kinase

仅限科研使用

Cat No : CM15062

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Synonyms

验证数据展示

  • CAS No.: 2300982-44-7

    RIPK1-IN-7
    CAS#: 2300982-44-7

产品信息

RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.

CAS号 2300982-44-7
分子式 C25H22F3N5O2
主要靶点 RIP kinase
主要通路 NF-κB信号通路|凋亡
分子量 481.47
纯度 98.02%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

RIPK1:(kd)4 nM |RIPK1:11 nM

体外活性

In the TSZ-induced HT29 cell necroptosis model, RIPK1-IN-7 shows potent cell protection effect (EC50 of 2nM). RIPK1-IN-7 displays considerable activity against several other kinases(Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively).

溶解度

DMSO:60 mg/mL (124.62 mM),Sonification is recommended.,H2O:0.1 mg/mL (insoluble)

参考文献

1.Li Y, et al. Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model. J Med Chem. 2018 Dec 27;61(24):11398-11414.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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