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RNASEH2B Polyclonal antibody

RNASEH2B Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 17527-1-AP

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Synonyms

AGS2, DLEU8, Ribonuclease H2 subunit B, ribonuclease H2, subunit B, Ribonuclease HI subunit B, RNase H2 subunit B, RNASEH2B



经过测试的应用

Positive WB detected inmouse thymus tissue, HeLa cells, MCF-7 cells, mouse lung tissue

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

17527-1-AP targets RNASEH2B in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, ELISA Application Description
Cited ApplicationsWB
Tested Reactivity human, mouse, rat
Cited Reactivityhuman, rat
Immunogen RNASEH2B fusion protein Ag11189 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name ribonuclease H2, subunit B
Synonyms AGS2, DLEU8, Ribonuclease H2 subunit B, ribonuclease H2, subunit B, Ribonuclease HI subunit B, RNase H2 subunit B, RNASEH2B
Calculated Molecular Weight 331 aa, 37 kDa
Observed Molecular Weight 35 kDa
GenBank Accession NumberBC036744
Gene Symbol RNASEH2B
Gene ID (NCBI) 79621
RRIDAB_10597401
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ5TBB1
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Ribonuclease H2 is the major nuclear enzyme degrading cellular RNA/DNA hybrids in eukaryotes and the sole nuclease known to be able to hydrolyze ribonucleotides misincorporated during genomic replication. RNASEH2B and RNASEH2C are the non-catalytic subunits of RNase H2 complex. Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2), a genetically heterogeneous disease with clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process.

实验方案

Product Specific Protocols
WB protocol for RNASEH2B antibody 17527-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
ratWB

Nutr Metab (Lond)

Integrative proteomic and lipidomic analysis of Kaili Sour Soup-mediated attenuation of high-fat diet-induced nonalcoholic fatty liver disease in a rat model.

Authors - Shuo Cong
humanWB

Cell Rep

Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition

Authors - Yan Li
  • KD Validated