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RO-5963

RO-5963是p53-MDM2和p53-MDMX 的双重抑制剂（IC50s:~17nM 和~24nM）。

CAS号

1416663-77-8

分子式

C24H21ClF2N4O5

主要靶点

Mdm2|p53

仅限科研使用

Cat No : CM20679

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Synonyms

验证数据展示

  • CAS No.: 1416663-77-8

    RO-5963
    CAS#: 1416663-77-8

产品信息

RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).

CAS号 1416663-77-8
分子式 C24H21ClF2N4O5
主要靶点 Mdm2|p53
主要通路 凋亡
分子量 518.9
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

p53-MDMX:~24 nM|p53-MDM2:~17 nM

体外活性

RO-5963 (10 μM, 24 hours) potently activates p53 and elevates p21 and MDM2 levels. RO-5963 (10-20 μM; 48 hours) displays much higher apoptotic activity than Nutlin in both MCF7 and ZR75-30 cell lines [1].

溶解度

DMSO:50 mg/mL (96.36 mM)

参考文献

1.Graves B, et al. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11788-93.

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