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ROR2 Polyclonal antibody

ROR2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 25842-1-AP

Print datasheet

Synonyms

BDB, BDB1, NTRKR2, ROR2

验证数据展示

  • WB analysis using 25842-1-AP

    WB analysis using 25842-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 25842-1-AP (ROR2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours.

经过测试的应用

Positive WB detected inHeLa cells, HepG2 cells, T-47D cells, K-562 cells

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:8000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

The immunogen of 25842-1-AP is ROR2 Fusion Protein expressed in E. coli.

Tested Applications WB, ELISA Application Description
Tested Reactivity human
Immunogen ROR2 fusion protein Ag22959 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name receptor tyrosine kinase-like orphan receptor 2
Synonyms BDB, BDB1, NTRKR2, ROR2
Calculated Molecular Weight 943 aa, 105 kDa
Observed Molecular Weight105 kDa
GenBank Accession NumberBC130522
Gene Symbol ROR2
Gene ID (NCBI) 4920
RRIDAB_2918094
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ01974
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Tyrosine-protein kinase transmembrane receptor ROR2 belongs to the ROR-family of receptor tyrosine kinases (RTKs) (PMID: 12815588). ROR2 is a developmentally regulated protein that has significant expression and roles in a wide variety of tissues during early embryonic development. It was established that ROR2 plays a key role in skeletal and neural organogenesis, as well as in midgut development in the mouse, but then becomes repressed in adult tissues. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PMID: 25614331). Mutations in ROR2 gene are associated with autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B (PMID: 12815588).

实验方案

Product Specific Protocols
WB protocol for ROR2 antibody 25842-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols