验证数据展示
产品信息
67906-1-PBS targets ROR2 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | Human, Mouse, Rat |
| 免疫原 | ROR2 fusion protein Ag31197 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | receptor tyrosine kinase-like orphan receptor 2 |
| 别名 | BDB, BDB1, NTRKR2, ROR2 |
| 计算分子量 | 943 aa, 105 kDa |
| 观测分子量 | 105 kDa |
| GenBank蛋白编号 | BC130522 |
| 基因名称 | ROR2 |
| Gene ID (NCBI) | 4920 |
| RRID | AB_2918662 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | Q01974 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Tyrosine-protein kinase transmembrane receptor ROR2 belongs to the ROR family of receptor tyrosine kinases (RTKs) (PMID: 12815588). ROR2 is a developmentally regulated protein that has significant expression and roles in a wide variety of tissues during early embryonic development. It was established that ROR2 plays a key role in skeletal and neural organogenesis, as well as in midgut development in the mouse, but then becomes repressed in adult tissues. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PMID: 25614331). Mutations in the ROR2 gene are associated with autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B (PMID: 12815588).
