验证数据展示
产品信息
67906-1-PBS targets ROR2 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.
| Tested Applications | WB, Indirect ELISA Application Description |
| Tested Reactivity | Human, Mouse, Rat |
| Immunogen | ROR2 fusion protein Ag31197 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | receptor tyrosine kinase-like orphan receptor 2 |
| Synonyms | BDB, BDB1, NTRKR2, ROR2 |
| Calculated Molecular Weight | 943 aa, 105 kDa |
| Observed Molecular Weight | 105 kDa |
| GenBank Accession Number | BC130522 |
| Gene Symbol | ROR2 |
| Gene ID (NCBI) | 4920 |
| RRID | AB_2918662 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q01974 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Tyrosine-protein kinase transmembrane receptor ROR2 belongs to the ROR family of receptor tyrosine kinases (RTKs) (PMID: 12815588). ROR2 is a developmentally regulated protein that has significant expression and roles in a wide variety of tissues during early embryonic development. It was established that ROR2 plays a key role in skeletal and neural organogenesis, as well as in midgut development in the mouse, but then becomes repressed in adult tissues. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PMID: 25614331). Mutations in the ROR2 gene are associated with autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B (PMID: 12815588).
