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RYR1 Monoclonal antibody, PBS Only

RYR1 Monoclonal Antibody for IHC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse

Applications

IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1B4E12

Cat no : 66539-1-PBS

Print datasheet

Synonyms

CCO, MHS, MHS1, Ryanodine receptor 1, RYDR, RYR, RYR 1, RYR1, SKRR

验证数据展示

  • IHC staining of mouse skeletal muscle using 66539-1-Ig (same clone as 66539-1-PBS)

    IHC staining of mouse skeletal muscle using 66539-1-Ig (same clone as 66539-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 66539-1-Ig (RYR1 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66539-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse skeletal muscle using 66539-1-Ig (same clone as 66539-1-PBS)

    IHC staining of mouse skeletal muscle using 66539-1-Ig (same clone as 66539-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 66539-1-Ig (RYR1 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66539-1-PBS in a different storage buffer formulation.

产品信息

66539-1-PBS targets RYR1 in IHC, Indirect ELISA applications and shows reactivity with Human, Mouse samples.

Tested Applications IHC, Indirect ELISA Application Description
Tested Reactivity Human, Mouse
Immunogen RYR1 fusion protein Ag25120 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name ryanodine receptor 1 (skeletal)
Synonyms CCO, MHS, MHS1, Ryanodine receptor 1, RYDR, RYR, RYR 1, RYR1, SKRR
Calculated Molecular Weight 565 kDa
GenBank Accession NumberNM_000540
Gene Symbol RYR1
Gene ID (NCBI) 6261
RRIDAB_2881901
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Ryanodine receptor isoform-1 (RyR1) is a major calcium channel in skeletal muscle important for excitation-contraction coupling. The transmembrane region of RyR1 is comprised of two domains including the pseudo voltage sensor domain and the pore-forming domain (PMID: 27855725). Dominant RyR1 mutations are the leading cause of MH. Studies on the Ca2+ conducting properties of RyR1 channels containing Malignant hyperthermia mutations expressed in myotubes.