Recombinant CTBP2 protein

Recombinant CTBP2 protein is supplied in 25 mM Tris-HCl pH 8.0, 500 mM NaCl, 10% glycerol, 0.5 mM TCEP.

CTBP2 (C-Terminal Binding Protein 2), also written as CtBP2, is a protein that binds to the C-terminus of adenovirus E1A proteins. It ubiquitously expresses with 2 higher level in heart, skeletal muscle, pancreas, associating to adenovirus E1A, C terminal proteins, involved with histone deacetylase and E2F3 in transcription repression. CTBP2 is a corepressor targeting diverse transcription regulators. It functions in brown adipose tissue (BAT) differentiation (By similarity). CTBP1 gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. This product is isoform 1. CTBP2 and another C-Terminal Binding Protein, CTBP1 can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development.

This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for this product is shown.

Recombinant CTBP2 protein was expressed in E.coli as the full length protein (accession number NP_001320.1) with an N-terminal 6xHis Tag. The molecular weight of the protein is 52.5 kDa.

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.