Recombinant FTO protein

Expressed In

Baculovirus

Protein Species

Human

Cat No : 31572,31972 31572



产品信息

Expressed In Baculovirus
Protein Species Human

Contents

Recombinant FTO protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl,10% glycerol, 0.04% Triton X-100, and 0.5 mM TCEP.

背景介绍

FTO (Alpha-Ketoglutarate Dependent Dioxygenase, also known as GDFD, ALKBH9, BMIQ14) is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily. FTO specifically demethylates m6A RNA. FTO plays an important role in the regulation of the global metabolic rate, energy expenditure and energy homeostasis. It is involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells.

Application Notes

This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for a given product is shown on the lot-specific Technical Data Sheet.

Protein Details

Recombinant FTO protein was expressed in baculovirus expression system as the full length protein (accession number XP_011521615.1) with an N-terminal FLAG tag. The molecular weight of FTO is 60.4 kDa.

Storage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.