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Rhynchophylline

Rhynchophylline (Mitrinermine) 是一种生物碱类化合物，从钩藤中分离得到，具有很高的生物活性，被广泛用于抗炎、神经保护等方面的研究。

CAS号

76-66-4

分子式

C22H28N2O4

主要靶点

NF-κB|Calcium Channel

仅限科研使用

Cat No : CM03247

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Synonyms

Mitrinermin|Rhyncophylline|Mitrinermine|Rhynchophyllin|钩藤碱

验证数据展示

  • CAS No.: 76-66-4

    Rhynchophylline
    CAS#: 76-66-4

产品信息

1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in cultured neurons in vitro. 3. Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia.

CAS号 76-66-4
分子式 C22H28N2O4
主要靶点 NF-κB|Calcium Channel
主要通路 代谢|NF-κB信号通路|离子通道
分子量 384.47
纯度 99.44%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Mitrinermin|Rhyncophylline|Mitrinermine|Rhynchophyllin|钩藤碱

溶解度

DMSO:25 mg/mL (65.02 mM)

参考文献

1.He Y , Zeng S Y , Zhou S W , et al. Effects of rhynchophylline on GluN1 and GluN2B expressions in primary cultured hippocampal neurons[J]. Fitoterapia, 2014, 98:166-173.

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