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Rituximab

Rituximab 是抗 CD20 嵌合单克隆抗体，用于研究某些自身免疫疾病和癌症。

CAS号

174722-31-7

分子式

主要靶点

Others

仅限科研使用

Cat No : CM06941

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Synonyms

验证数据展示

  • CAS No.: 174722-31-7

    Rituximab
    CAS#: 174722-31-7

产品信息

Rituximab anti-CD20) is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM.

CAS号 174722-31-7
分子式
主要靶点 Others
主要通路 其他
分子量 148 kDa
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at -20 ℃
别名

细胞实验

Objective: Complement-mediated cell lysis. Concentrations: 0, 0.02, 0.2, 2, 20 μg/mL. Incubation Time: 2 h. Method: Lymphoma B cells were purified from lymph node biopsies of patients with B-cell lymphoma. Rituximab was added to tumor cells (1×106 /mL) in complete medium supplemented by human serum, inactivated or not by incubation at 56°C for 30 minutes. After 2 hours at 37°C, cell lysis was determined by PI staining of cells and analysis by flow cytometry.

参考文献

1.Du J, et al. Structural basis for recognition of CD20 by therapeutic antibody Rituximab. J Biol Chem. 2007 May 18;282(20).
2.George J. et al. Rituximab: mechanism of action.Semin Hematol. 2010 April ; 47(2): 115–123.
3.Chow KU, et al. Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases. Haematologica. 2002 Jan;87(1):33-43.
4.Schliemann C, et al. Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2. Blood. 2009 Mar 5;113(10):2275-83.
5.Cartron G, et al. Pharmacokinetics of rituximab and its clinical use: thought for the best use  Crit Rev Oncol Hematol. 2007 Apr;62(1):43-52.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2