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Rotundine

Rotundine (Gindarine) 是多巴胺D1、D2和D3受体的拮抗剂，IC50值分别为 166、1.4 和 3.3 μM。 它也是5-HT1A 的拮抗剂，IC50值为 370 nM。

CAS号

483-14-7

分子式

C21H25NO4

主要靶点

Dopamine Receptor|5-HT Receptor

仅限科研使用

Cat No : CM00485

Print datasheet

Synonyms

Gindarine|L-Tetrahydropalmatine|Caseanine|罗通定|(-)-Tetrahydropalmatine

验证数据展示

  • CAS No.: 483-14-7

    Rotundine
    CAS#: 483-14-7

产品信息

Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.

CAS号 483-14-7
分子式 C21H25NO4
主要靶点 Dopamine Receptor|5-HT Receptor
主要通路 G蛋白偶联受体|神经科学
分子量 355.43
纯度 99.73%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Gindarine|L-Tetrahydropalmatine|Caseanine|罗通定|(-)-Tetrahydropalmatine

靶点活性

D1 receptor:166 nM

体外活性

Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3]

溶解度

Ethanol:<1 mg/mL,H2O:<1 mg/mL,DMSO:8 mg/mL (22.5 mM)

参考文献

1.Wang JB, et al. Future Med Chem, 2012, 4(2), 177-186.
2.Liu YL, et al. Acta Pharmacol Sin, 2005, 26(5), 533-538.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2