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SBE13 Hydrochloride

SBE13 Hydrochloride (SBE 13 HCl) 是一种选择性的Plk1抑制剂，IC50值为 0.2 nM，对 Plk2 的IC50>66 μM，Plk3的IC50值为875 nM。

CAS号

1052532-15-6

分子式

C24H28Cl2N2O4

主要靶点

PLK|Apoptosis|Autophagy

仅限科研使用

Cat No : CM06041

Print datasheet

Synonyms

SBE 13 hydrochloride|SBE 13 HCl

验证数据展示

  • CAS No.: 1052532-15-6

    SBE13 Hydrochloride
    CAS#: 1052532-15-6

产品信息

SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.

CAS号 1052532-15-6
分子式 C24H28Cl2N2O4
主要靶点 PLK|Apoptosis|Autophagy
主要通路 细胞周期|凋亡|自噬
分子量 479.4
纯度 99.01%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 SBE 13 hydrochloride|SBE 13 HCl

靶点活性

PLK1:0.2 nM

体内活性

SBE 13不损害原代细胞的细胞周期及增殖,但会使各种癌细胞株的增殖降低,并造成G2/M阻滞,促使细胞凋亡。 SBE13与恩扎妥林联用对减少细胞增殖具有协同作用,并使HCT116(p53-/-)细胞的凋亡诱导增强。

溶解度

DMSO:47.9 mg/mL (100 mM),H2O:4.8 mg/mL (10 mM)),with gentle warming

细胞实验

Cells are treated with SBE13 one day after subculturing. Control cells are incubated with normal culture medium. Concentrations of SBE13 ranged from 1 nM–100 μM. The growth rate of 1 x 105 cells per 6-well is determined by counting cells at 24, 48 and 72 hours after treatment. Cell culture studies are performed in triplicate for each time point.(Only for Reference)

参考文献

1.Keppner S, et al. Cell Cycle. 2010, 9(4), 761-773.
2.Keppner S, et al. Cell Cycle. 2011, 10(4), 708-720.
3.Lange L, et al. Oncotarget. 2014, 5(8), 2263-2275.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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