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SCH442416

SCH442416 (SCH 442416) 是选择性和可透过血脑屏障的腺苷A2A 受体拮抗剂，对人和大鼠 A2AR 的Ki 值分别为 0.048 和 0.5 nM，可用于在大鼠和灵长类动物大脑中对腺苷 A2A 受体成像。

CAS号

316173-57-6

分子式

C20H19N7O2

主要靶点

Adenosine Receptor

仅限科研使用

Cat No : CM02537

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Synonyms

SCH 442416|2-(2-呋喃基)-7-[3-(4-甲氧苯基)丙基]-7H-吡唑并[4,3-E][1,2,4]三唑并[1,5-C]嘧啶-5-胺

验证数据展示

  • CAS No.: 316173-57-6

    SCH442416
    CAS#: 316173-57-6

产品信息

SCH-442416 is an selective antagonist of adenosine A2A receptor. SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).

CAS号 316173-57-6
分子式 C20H19N7O2
主要靶点 Adenosine Receptor
主要通路 G蛋白偶联受体|神经科学
分子量 389.42
纯度 99.95%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 SCH 442416|2-(2-呋喃基)-7-[3-(4-甲氧苯基)丙基]-7H-吡唑并[4,3-E][1,2,4]三唑并[1,5-C]嘧啶-5-胺

靶点活性

rA2AR:0.5 nM (IC50)|hA2AR:0.048 nM (IC50)

体外活性

The A2A receptor antagonist (SCH 442416) could increase mRNA expression of the Kir 2.1and Kir 4.1 channels in Müller cells to protect the retinal neurons in vitro under hypoxic conditions[1].

溶解度

DMSO:60 mg/ml (154.08 mM)

参考文献

1.Kang X , Yu J , Wei Y , et al. The Effect of A 2A Receptor Antagonist (SCH 442416) on the mRNA Expression of Kir 2.1 and Kir 4.1 Channels in Rat Retinal Müller Cells Under Hypoxic Conditions in Vitro[J]. Advances in Clinical and Experimental Medicine, 2013, 22(6):825-829.
2.Jun Yu , Yan Yan , Yiye Chen,et al. A 2A R Antagonists Upregulate Expression of GS and GLAST in Rat Hypoxia Model.Biomed Res Int. 2020 Oct 26;2020:2054293. doi: 10.1155/2020/2054293. eCollection 2020.

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