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验证数据展示

  • WB analysis using 27551-1-AP

    WB analysis using 27551-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 27551-1-AP (SCN2A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

  • IF Staining of mouse brain using 27551-1-AP

    IF Staining of mouse brain using 27551-1-AP

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using SCN2A antibody (27551-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

SCN2A Polyclonal antibody

SCN2A Polyclonal Antibody for WB, IF-P, ELISA
Cat No. 27551-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IF-P, ELISA

别名

Na(v)1.2, HBSCII, HBSCI, HBSC II, HBA

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive WB detected inHEK-293 cells
Positive IF-P detected inmouse brain tissue

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:2000
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

27551-1-AP targets SCN2A in WB, IF-P, ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IF-P, ELISA Application Description
经测试反应性 human, mouse
免疫原 SCN2A fusion protein Ag26022 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 sodium channel, voltage-gated, type II, alpha subunit
别名 Na(v)1.2, HBSCII, HBSCI, HBSC II, HBA
计算分子量 228 kDa
观测分子量~250 kDa
GenBank蛋白编号NM_001040142
基因名称 SCN2A
Gene ID (NCBI) 6326
RRIDAB_3085969
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ99250
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

The Sodium Channel, Voltage-Gated, Type II, Alpha (SCN2A) gene encodes the neuronal sodium channel NaV1.2. There are two major developmentally regulated splice isoforms of NaV1.2 that use mutually exclusive copies of the fifth coding exon and differ by one amino acid at position 209: Asparagine (Asn/N) vs. Aspartic acid (Asp/D). NaV1.2 is one of several sodium channels involved in initiation and propagation of action potentials in neurons. It's widely expressed throughout the human central nervous system, but not in peripheral tissues. (PMID: 29691040)

实验方案

Product Specific Protocols
WB protocol for SCN2A antibody 27551-1-APDownload protocol
IF protocol for SCN2A antibody 27551-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols