SCP2/SCPx Polyclonal antibody
SCP2/SCPx Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
ELISA and More (1)
Conjugate
Unconjugated
验证数据展示
发表文章中的应用
| WB | See 4 publications below |
产品信息
19182-1-AP targets SCP2/SCPx in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Applications | ELISA Application Description |
| Cited Applications | WB |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | rat |
| Immunogen | SCP2/SCPx fusion protein Ag6002 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | sterol carrier protein 2 |
| Synonyms | NLTP, NSL TP, SCP 2, SCP chi, SCP X, SCP2, sterol carrier protein 2, Sterol carrier protein X |
| Calculated Molecular Weight | 59 kDa |
| Observed Molecular Weight | 46 kDa, 58 kDa |
| GenBank Accession Number | BC067108 |
| Gene Symbol | SCP2 |
| Gene ID (NCBI) | 6342 |
| RRID | AB_10603471 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P22307 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
SCP2 (Sterol carrier protein-2), also called nonspecific lipid-transfer protein, is thought to play a major role in intracellular lipid transport and metabolism. Mutations of SCP2 have been associated with diseases involving abnormalities in lipid trafficking, such as Zellweger syndrome. The alternative splicing generates 58 kDa SCPx and 13-15 kDa SCP2 proteins, both of which contain a C-terninal SCP2 domain. In addition to the SCP2 domain, SCPx also contains an amino-terminal thiolase domain. The proteolytic cleavage of SCPx occurred when it was imported into peroxisomes, giving rise to a 44-46 kDa thiolase and a 13-15 kDa SCP2. 19182-1-AP antibody recognizes the intact 58 kDa SCPx protein as well as 44-46 kDa thiolase.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for SCP2/SCPx antibody 19182-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
J Biol Chem A Cargo-centered Perspective on the PEX5 Receptor-mediated Peroxisomal Protein Import Pathway. | ||
FEBS J Membrane topologies of PEX13 and PEX14 provide new insights on the mechanism of protein import into peroxisomes. | ||
J Biol Chem The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo. | ||
Methods Mol Biol Determining the Topology of Peroxisomal Proteins Using Protease Protection Assays. |
