验证数据展示
产品信息
66588-1-PBS targets SDHA as part of a matched antibody pair:
MP50790-1: 66588-1-PBS capture and 66588-2-PBS detection (validated in Cytometric bead array)
MP50790-2: 66588-1-PBS capture and 66588-3-PBS detection (validated in Cytometric bead array)
MP50790-3: 66588-1-PBS capture and 66588-4-PBS detection (validated in Cytometric bead array)
Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
Tested Applications | WB, IHC, IF/ICC, Cytometric bead array, Indirect ELISA Application Description |
Tested Reactivity | human, mouse, rat, pig, rabbit |
Immunogen | SDHA fusion protein Ag7023 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) |
Synonyms | PPGL5, PGL5, MC2DN1, FP, EC:1.3.5.1 |
Calculated Molecular Weight | 73 kDa |
Observed Molecular Weight | 62-73 kDa |
GenBank Accession Number | BC001380 |
Gene Symbol | SDHA |
Gene ID (NCBI) | 6389 |
RRID | AB_2881948 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P31040 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
SDHA, also named as SDH2, SDHF and Fp, belongs to the FAD-dependent oxidoreductase 2 family and FRD/SDH subfamily. SDHA is the flavoprotein subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDHA has 3 isoforms with the molecular mass of 73, 67 and 57 kDa, and the N-terminal (~5 kDa) can be removed in mature form. It can be detected a band of 68 kDa in cutaneous melanoma(PMID:21698147). SDHA may act as a tumor suppressor.