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SEW​2871

SEW 2871 是一种可口服的高选择性 S1P1激动剂，EC50为 13.8 nM。它减少血液中的淋巴细胞数量，可用于糖尿病、阿尔茨海默氏病、肝纤维化和炎症相关研究。它激活 ERK、Akt 和 Rac 信号通路，并诱导 S1P1 内在化和再循环。

CAS号

256414-75-2

分子式

C20H10F6N2OS

主要靶点

LPL Receptor|S1P Receptor

仅限科研使用

Cat No : CM04988

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Synonyms

SEW2871

验证数据展示

  • CAS No.: 256414-75-2

    SEW​2871
    CAS#: 256414-75-2

产品信息

SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.

CAS号 256414-75-2
分子式 C20H10F6N2OS
主要靶点 LPL Receptor|S1P Receptor
主要通路 G蛋白偶联受体
分子量 440.36
纯度 99.62%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 SEW2871

靶点活性

S1P1:13.8 nM (EC50)

溶解度

DMSO:8.8 mg/mL(20 mM)

参考文献

1.Ni Q, et al. Int Immunopharmacol. 2015 May;26(1):37-42.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2