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SEZ6L2 Polyclonal antibody

SEZ6L2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 19428-1-AP

Print datasheet

Synonyms

PSK, PSK 1, Seizure 6 like protein 2, SEZ6L2

验证数据展示

  • WB analysis using 19428-1-AP

    WB analysis using 19428-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 19428-1-AP (SEZ6L2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

经过测试的应用

Positive WB detected inmouse brain tissue, rat brain tissue

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:4000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

19428-1-AP targets SEZ6L2 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen SEZ6L2 fusion protein Ag13760 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name seizure related 6 homolog (mouse)-like 2
Synonyms PSK, PSK 1, Seizure 6 like protein 2, SEZ6L2
Calculated Molecular Weight 910 aa, 98 kDa
Observed Molecular Weight150 kDa
GenBank Accession NumberBC000567
Gene Symbol SEZ6L2
Gene ID (NCBI) 26470
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ6UXD5
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Seizure 6-like protein 2 (SEZ6L2) is a type 1 transmembrane protein predominantly expressed in the brain. It belongs to the seizure-related gene 6 (SEZ6) family, which contains SEZ6, SEZ6L and SEZ6L2. SEZ6 family members have been shown to influence synapse numbers and dendritic morphology and are linked to various neurological and psychiatric disorders (PMID: 33936031). SEZ6L2 is a part of the AMPA receptor and acts as a scaffolding protein to link GluR1 to adducin (PMID: 29032200). Overexpression of SEZ6L2 has been reported in a variety of cancers, including lung cancer, hepatocellular carcinoma, thyroid carcinoma, cholangiocarcinoma (PMID: 16863507; 35117286; 35284305; 32148567). SEZ6L2 can be glycosylated and the apparent molecular weight can be raised to 150-170 kDa (PMID: 26698217; 24272587).

实验方案

Product Specific Protocols
WB protocol for SEZ6L2 antibody 19428-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols