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SIRT2-IN-9

SIRT2-IN-9 是一种具有选择性的SRIT2抑制剂，IC50值为 1.3 μM。SIRT2-IN-9对MCF-7 乳腺癌细胞的增殖有抑制作用。SIRT2-IN-9 可用于研究癌症。

CAS号

522650-91-5

分子式

C21H22N6OS2

主要靶点

Sirtuin

仅限科研使用

Cat No : CM11540

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Synonyms

验证数据展示

  • CAS No.: 522650-91-5

    SIRT2-IN-9
    CAS#: 522650-91-5

产品信息

SIRT2-IN-9 is a selective SRIT2 inhibitor with an IC50 value of 1.3 μM.SIRT2-IN-9 inhibits the proliferation of MCF-7 breast cancer cells.SIRT2-IN-9 can be used for cancer research.

CAS号 522650-91-5
分子式 C21H22N6OS2
主要靶点 Sirtuin
主要通路 DNA损伤和修复|表观遗传
分子量 438.57
纯度 99.50%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
别名

靶点活性

SIRT2:1.3 μM

体外活性

SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SRIT2 (IC50=1.3 μM), and inhibits SRIT1 and SRIT3 (IC50s＞300 μM).[1] SIRT2-IN-9 (0-50 μM; 72 h) affects the cell viability of MCF-7 cells and dose-dependently inhibited cell proliferation of MCF-7 breast cancer cells.[1] SIRT2-IN-9 (0-50 μM; 6 h) affects acetylation of α-tubulin protein.[1]

溶解度

DMSO:4.0 mg/mL (9.2 mM),ultrasonic and warming and heat to 70°C

参考文献

1.Yang SY, et al. The purposes of 5H- [1,2,4] triazine [5,6-b] indole derivatives of 3 substitutions. CN108309982A. 2017.

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