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  • Featured Product
  • KD/KO Validated

SIRT6 Monoclonal antibody, PBS Only

SIRT6 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2H4G8

Cat no : 67510-1-PBS

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Synonyms

NAD-dependent protein deacetylase sirtuin-6, hSIRT6, EC:2.4.2.-, EC:2.3.1.286, EC:2.3.1.-

验证数据展示

  • WB analysis using 67510-1-Ig (same clone as 67510-1-PBS)

    WB analysis using 67510-1-Ig (same clone as 67510-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67510-1-Ig (SIRT6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

  • WB analysis of Jurkat using 67510-1-Ig (same clone as 67510-1-PBS)

    WB analysis of Jurkat using 67510-1-Ig (same clone as 67510-1-PBS)

    WB result of SIRT6 antibody (67510-1-Ig; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-SIRT6 transfected Jurkat cells. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

产品信息

67510-1-PBS targets SIRT6 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen SIRT6 fusion protein Ag24103 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
Synonyms NAD-dependent protein deacetylase sirtuin-6, hSIRT6, EC:2.4.2.-, EC:2.3.1.286, EC:2.3.1.-
Calculated Molecular Weight 39 kDa
Observed Molecular Weight 40 kDa
GenBank Accession NumberBC028220
Gene Symbol SIRT6
Gene ID (NCBI) 51548
RRIDAB_2882731
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ8N6T7
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SIRT6, also named as SIR2L6, belongs to the sirtuin family. It is known to deacetylate H3K9, H3K56 and CtIP in vivo. SIRT6 regulates the expression of a large number of stress-responsive and metabolism related genes, promotes genomic stability and stimulates base excision and double strand break DNA repair(PMID: 20729089). By maintaining both the integrity and the expression of the mammalian genome, SIRT6 thus serves several roles that parallel Sir2 function(PMID: 20729089). In addtion, Sirt6-deficient animals develop normally for several weeks after birth, but succumb to an acute multi-organ degenerative syndrome that is uniformly lethal by one month of age(PMID: 19135889).