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验证数据展示

  • WB analysis using 67510-1-Ig (same clone as 67510-1-PBS)

    WB analysis using 67510-1-Ig (same clone as 67510-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67510-1-Ig (SIRT6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

  • WB analysis of Jurkat using 67510-1-Ig (same clone as 67510-1-PBS)

    WB analysis of Jurkat using 67510-1-Ig (same clone as 67510-1-PBS)

    WB result of SIRT6 antibody (67510-1-Ig; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-SIRT6 transfected Jurkat cells. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

SIRT6 Monoclonal antibody, PBS Only

SIRT6 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67510-1-PBS

产品说明书

CloneNo. 2H4G8

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse

应用

WB, Indirect ELISA

别名

NAD-dependent protein deacetylase sirtuin-6, hSIRT6, EC:2.4.2.-, EC:2.3.1.286, EC:2.3.1.-

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy SIRT6 Ready-To-Use IHC Kit. SIRT6 primary antibody included.

产品信息

67510-1-PBS targets SIRT6 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 SIRT6 fusion protein Ag24103 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
别名 NAD-dependent protein deacetylase sirtuin-6, hSIRT6, EC:2.4.2.-, EC:2.3.1.286, EC:2.3.1.-
计算分子量 39 kDa
观测分子量 40 kDa
GenBank蛋白编号BC028220
基因名称 SIRT6
Gene ID (NCBI) 51548
RRIDAB_2882731
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDQ8N6T7
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SIRT6, also named as SIR2L6, belongs to the sirtuin family. It is known to deacetylate H3K9, H3K56 and CtIP in vivo. SIRT6 regulates the expression of a large number of stress-responsive and metabolism related genes, promotes genomic stability and stimulates base excision and double strand break DNA repair(PMID: 20729089). By maintaining both the integrity and the expression of the mammalian genome, SIRT6 thus serves several roles that parallel Sir2 function(PMID: 20729089). In addtion, Sirt6-deficient animals develop normally for several weeks after birth, but succumb to an acute multi-organ degenerative syndrome that is uniformly lethal by one month of age(PMID: 19135889).